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desvenlafaxine will improve the amount or impact of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Warning/Monitor. Desvenlafaxine inhibits CYP2D6; with bigger desvenlafaxine doses (ie, 400 mg) decrease the CYP2D6 substrate dose by around fifty%; no dosage adjustment essential with desvenlafaxine doses seven consecutive times immediat